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Guard theory : ウィキペディア英語版 | Guard theory
Guard theory is a branch of immunology which concerns the innate sensing of stereotypical consequences of a virulence factor or pathogen.〔Innovating immunology: an interview with Ruslan Medzhitov. Disease Models & Mechanisms 2011;4(4):430-432. doi:10.1242/dmm.008151.〕 This is in contrast to the classical understanding of recognition by the innate immune system, which involves recognition of distinct microbial structures- pathogen-associated molecular patterns (PAMPs)- with pattern recognition receptors (PRRs). Some of these stereotypical consequences of virulence factors and pathogens may include altered endosomal trafficking and changes in the cytoskeleton.〔Innovating immunology: an interview with Ruslan Medzhitov. Disease Models & Mechanisms 2011;4(4):430-432. doi:10.1242/dmm.008151.〕 These recognition mechanisms would work to complement classical pattern recognition mechanisms.〔Innovating immunology: an interview with Ruslan Medzhitov. Disease Models & Mechanisms 2011;4(4):430-432. doi:10.1242/dmm.008151.〕 == Mechanism ==
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